The New York Blood Center (NYBC) is a community, nonprofit blood bank based in New York City. Established in 1964 by Dr. Aaron Kellner.

The current headquarter offices are the NYBC Offices on 310 East 67th Street. The organisation maintains several research locations, as well as a number of blood banks locations in New York City.

Most of the blood drives organized by the organisation are hosted by other groups, helping to keep the real estate cost down, but making quality assurance and provenance a priority.