I think it would be worth bringing this up as people are starting to make witch characters.
So could there be a couple check boxes added to attack rolls, saves, skills that include Fortune and Misfortune. So the dice roller will know to roll the d20 for the attacks, saves and skills twice and take either the higher roll or lower roll for which ever hex was checked?
This way players and DM's don't have to just roll all their attacks twice and figure out which one applies to which attack, save, skill roll as it's done automagically.